Macular hole repair- decellularized human amniotic membrane (hAM)-overlay technique

Large or chronic macular holes can be some of the most challenging cases we see in retina surgery, especially when they’ve been present for years or are tied to conditions like retinal detachment or high myopia. At Retina World Congress, Dr. Deepika Malik, shared her experience using bidirectional decellularized human amniotic membrane (hAM) overlay technique for macular holes between 800–1200 microns. This approach helps protect the retinal pigment epithelium during surgery, promotes better reattachment of photoreceptor terminals, and in her series, achieved an impressive ~90% anatomical closure rate at 6 months. Key takeaway? In the right cases, use of decellularized dehydrated amniotic membrane/basement membrane (Biovance/Biovance 3L Ocular) may be considered for secondary macular hole or high risk primary surgical repair delivering sustained hole closure and visual improvement. Financial DIsclosures: none References: Malik, D. Macular hole repair with bidirectional decellularized human amniotic membrane (hAM)-overlay technique. Presented at: Retina World Congress; 2025; Fort Lauderdale, FL.